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DeCS
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Descriptor English:
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Complement C1
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Descriptor Spanish:
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complemento C1
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Descriptor Portuguese:
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Complemento C1
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Synonyms English:
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C1 Complement
C1, Complement
Complement 1
Complement Component 1
Complement, C1
Component 1, Complement
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Tree Number:
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D12.776.124.486.274.050
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Definition English:
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The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION. |
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Indexing Annotation English:
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/antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS
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Pharmacological Action:
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Immunologic Factors
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History Note English:
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2006 (1975)
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Allowable Qualifiers English:
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Record Number:
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22133
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Unique Identifier:
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D003172
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Occurrence in VHL:
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Similar:
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DeCS
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